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The therapeutic effect of Fulvic acid on keratitis and hemorrhagic eye disease

Keratitis is characterized by inflammation of the cornea of the eye, while a hemorrhagic eye condition is characterized by profuse bleeding caused by hemorrhage or burst of the blood vessels of the eye.

Fulvic acid is an anti-inflammatory agent. It is also a blood coagulating and analgesic agent, capable of healing open wounds. From 1977 to 1981, Guofan Tang and his coworkers performed extensive studies in the area of ophthalmology and presented many reports with summaries. From March, 1981 to the end of July, 1982, they used fulvic acid in the treatment of 60 patients with eye diseases (total number of diseased eyes: 64). Control studies were conducted using other drugs on 30 randomly selected patients with similar eye problems.

Fulvic acid treatment group:

This group was treated with fulvic acid extracted from humic peat in the People’s Hospital preparation room in the Shaoxing area. Chemical analysis of the fulvic acid showed that the molecular weight was lower than 500, which fulfills the standard set by the National Fulvic Acid Symposium. It showed a stronger affinity toward the elemental mineral Beryllium, and was free of any radioactive material.   Two forms of reagents were available: an eye drop containing 0.5% fulvic acid in 10 ml bottles and an intramuscular injection reagent containing 0.5% fulvic acid solution in 2 ml ampoule. The latter was also able to be injected underneath the conjunctiva of the eye; or when mixed in 10% glucose solution, could be used as an intravenous injection.      For outer eye illness such as keratitis, 0.5% fulvic acid was used as an eye drop 4 times a day or every 2 hours; or, additionally, intramuscular injection using 2 ml of 0.5% fulvic acid twice a day.

For patients suffering from hemorrhagic eyes, intramuscular injection was performed with 2 ml of 0.5% fulvic acid, twice a day.

Whenever either the eyedrops or the injection containing fulvic acid was used, the dilator Atropine was applied. However, antiseptics and blood coagulating agents should be avoided.

The control group:

Patients with various ailments were selected at random. Multiple medications were used in order to speed up the healing and to relieve patients from pain. Eye drops containing Chloromycetin and ointments containing Tetracycline were used along with antibiotic injections. Some patients were also treated with intravenous injections of Chloromycetin and Tetracycline. Viral infections were given Anti-herpes eyedrops, Vitamin C and K, and Novacain, among other treatments and injections. For the hemorrhagic control group's conditions, intramuscular and intravenous injections were given using the common drugs for this purpose.

Eyesight examinations:

Prior to the treatment, patients in the fulvic acid and the control group were examined for their eyesight. Their eyes were examined externally and the back of their eyes were observed. When the treatment was in progress, examinations were conducted daily or every other day. Then results were compared and analyzed. Eyesight examinations were taken into consideration in the final analysis.

Case studies:

The keratitis group treated with fulvic acid consisted of a total of 26 cases.  Four of the hypo-keratitis cases were treated with end result being 50% effective. Eleven keratitis cases were caused by external injury and had a 90.9% success rate. Three keratitis cases were caused by viral infection and had a success rate of 100%. One keratitis case was caused by fungal infection and had a 100% success rate.  Six cases were considered to be simple forms of keratitis with an end success rate of 83.33%. One case was caused by bacillus bacteria and treatment was 100% effective. The combined success rate for all fulvic acid treated keratitis cases was 84.61%. 

The hemorrhagic eye group treated with fulvic acid consisted of a total of 34 patients.  Twenty had blood accumulated in the anterior chamber of the eye, six were caused by previous surgery and fourteen from external injury. Treatment for that group was 85% successful. Another ten patients had blood accumulated in the lens of the eye, two were from vein retinitis, two were caused by previous surgery, four from external injury, one was related to diabetes, one was related to high blood pressure. Total effectiveness for the second group was 60%. In the final group, four patients had hemorrhaged retina of the eye, with two caused by vein retinitis, one related to diabetes, and one from central venous thrombosis.  Success rate for the last group was 75%.  Total overall effectiveness of the fulvic acid treated hemorrhagic group was 76.5%.

The control group consisted of 30 patients with similar ailments that were selected at random. They were treated with a variety of all the best known drug therapies and antibiotics. The control keratitis group was rated at 83.33% total effectiveness, and the hemorrhagic group at 91.7%.

Analysis and discussion:

The above treatment shows that fulvic acid is an anti-inflammatory agent, and able to significantly enhance healing of ulcerous wounds and coagulate blood. Based on the treatment results of the two groups, together with data taken from extensive charts, literature, and vision tests, the final analysis and discussion are presented below:

Extensively documented and detailed results show that the control group, in general, uses medications consisting of more than 3 leading drugs, sometimes for a combination of treatments, for example: caused by localized burns, penetrating the anterior chamber, and antiseptics injected below conjunctiva. The final overall results are in no way better in comparison with the solitary treatment with fulvic acid.

From complex statistical studies, the therapeutic effectiveness of both groups shows no significant difference. Thus the therapeutic effectiveness of fulvic acid is not inferior in comparison with a combination of anti-bacteria and antibiotic treatments.

The effectiveness of the control group using more than 2 or 3 medications for treating hemorrhaged eye diseases is in no way better than those treated with fulvic acid as the only drug.

For patients with various ulcerous cornea ailments, the number of treatment days is equally effective for both fulvic acid and the control groups.

 Summary:

The effectiveness of fulvic acid as an anti-inflammatory agent and as a coagulant is nowhere less efficient compared with various anti-bacterial agents, antibiotics, or other blood coagulants. In addition, contrary to other anti-inflammatory drugs, fulvic acid does not have any side effects and in many cases is actually superior in effectiveness. Further advantages are availability and low cost of fulvic acid. Economically, fulvic acid has a uniqueness with these characteristics, and fulvic acid warrants further study and observation.

Guofan, Tang, Jiangxi Humic Acid, 3 (1984).  In: Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; Chapter 36; First Edition: June 1993.

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